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KMID : 0377619770330040314
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Korean Jungang Medical Journal
1977 Volume.33 No. 4 p.314 ~ p.346
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Study on the Effects of Intravenous Iron Preparation "Fesin79 in the Anemic Patients with Pregnancy Toxemia
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Abstract
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It is paradoxical that whilst iron is one of the less expensive and most readily available medicinal substances, its deficiency, particularly in the female population, still presents serious problems.
This study was performed for confirm to the effects of intravenous saccharated iron oxide, "Fesin" in 15 antepartum and 15 postpartum patients with pregnancy toxemia signs suffering from the anemia.
1) The safety, rapidity of the effect and tolerance of intravenous sacchrated oxide of iron among the pregnancy anemia with pregnancy toxemia.
2) The differences of the effect of the intravenous saccharated oxide of iron during antepartum and postpartum for the pregnancy anemia with pregnancy
toxemia.
About all patents, serum iron, hemoglobin, hematocrit, and reticulocy to count were checked at pretreatment, posttreatment 1st week, 2rld week, and 4th week, by the same technician. And observed any adverse effects occurring coincidentally. A 11 patients were administered iron slowly 500mg of saccharated iron oxide during 8 days through the intravenous route.
Results:
1) The effect was slightly greater in postpartum group than antepartum group.: Average rise of 1.96±0.24 gm % of hemoglobin in antepartum group within 4 weeks and 2.24±0.46gm% of hemoglobin in postpartum group for the same period.
2) Rising of the hemoglobin level shows from post treatment 1st week and the peak at 3rd or 4th week.
3) The lower the hemoglobin level at pretreatment, the greater increase of the hemoglobin level at post treatment 4th week.
4) Could not detect the difference of the effects in preeclampsia and eclampsia group.
5) Only 3.3% of 240 injections appeared adverse reactions pain at the site of injection, nausea, dizziness, discoloration at the site of injection, etc.
Belong to the above results, we thought intravenous saccharated oxide of iron for the treatment of iron deficiency anemia during pregnancy with pregnancy toxemia is especially effective in those patients who cannot tolerate iron by mouth, who have excessive nausea and vomiting of pregnancy, and who present themselves late in pregnancy with an existing anemia and insufficient time for response to oral therapy.
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